Journal article
Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation
Damián Hernández, Stephanie Morgan Schlicht, Jordan Elli Clarke, Maciej Daniszewski, Celeste M Karch, undefined Dominantly Inherited Alzheimer Network (DIAN), Alison M Goate, Alice Pébay
Stem Cell Research | Elsevier | Published : 2024
Abstract
We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.
Grants
Awarded by Deutsches Zentrum für Neurodegenerative Erkrankungen